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Clinical Trials Search at Vanderbilt-Ingram Cancer Center



A Trial of TAK-788 (AP32788) in Non-small Cell Lung Cancer (NSCLC)

Multiple Cancer Types

The purpose of this phase 1 / 2 study is to evaluate the safety, recommended phase 2 dose (RP2D), dose limiting toxicities (DLTs), maximum tolerated dose (MTD), pharmacokinetics of oral TAK-788, anti-tumor activity of TAK-788 in participants with NSCLC with epidermal growth factor receptor (EGFR) or human epidermal growth factor 2 (HER2), and anti-tumor activity of TAK-788 in participants with solid tumors other than NSCLC with EGFR or HER2 mutations, and to explore relationship between tumor and / or plasma biomarkers, and TAK-788 efficacy, safety, and / or cytochrome P450 3A (CYP3A) induction. The study will also determine the efficacy of TAK-788 in participants with locally advanced metastatic NSCLC harboring EGFR in-frame exon 20 insertion mutations who have received at least 1 prior line of therapy for locally advanced or metastatic NSCLC.
Lung, Non Small Cell
I/II
Horn, Leora
NCT02716116
VICCTHO1614

Long Term Follow-up for Early Detection of Lung Cancer in Current or Former Smokers

Lung

This research trial studies the long term follow-up for early detection of lung cancer in current or former smokers. Following up on smokers by collecting and analyzing specimens in the laboratory, performing chest computed tomography (CT) scans, as well as reviewing medical records may help doctors detect lung cancer at an earlier stage.
Lung
N/A
Massion, Pierre
NCT03181256
VICCTHO1730

Yttrium Y 90 Resin Microspheres in Collecting Data from Patients with Liver Cancer That Cannot Be Removed by Surgery for the RESIN Liver Tumor Study

Liver

This research trial studies Yttrium Y 90 resin microspheres in collecting data from patients with liver cancer not capable of being removed by surgery (unresectable) for the radiation-emitting SIR-spheres in non-resectable (RESIN) liver tumor study. The information generated will help doctors better understand treatment patterns involving Y90 therapy, gain additional insights in the long-term outcomes for patients, as well as guide future research for using Y90 therapy, especially for those conditions where data is currently very limited or lacking.
Liver
N/A
Brown, Daniel
NCT02685631
VICCGI1523

MRI in Measuring Tumor Growth and Treatment Response in Patients with Breast Tumors and Healthy Volunteers

This clinical trial studies magnetic resonance imaging (MRI) in measuring tumor growth and treatment response in patients with breast tumors and healthy volunteers. Diagnostic procedures, such as dynamic contrast enhanced MRI (DCE-MRI), diffusion weighted MRI (DW-MRI), and magnetic resonance spectroscopy (MRS), may help characterize breast tumors to develop potential surrogate imaging markers for diagnosis and treatment response.
Not Available
Pilot
Chak, Bapsi
NCT00474604
VICCBRE0588

Observation or Radiation Therapy in Treating Patients with Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery

Neuro-Oncology

This randomized phase III trial studies how well radiation therapy works compared with observation in treating patients with newly diagnosed grade II meningioma that has been completely removed by surgery. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors.
Neuro-Oncology
III
Chambless, Lola
NCT03180268
NRGNEUBN003

Bronchoscopy with Bronchoalveolar Lavage in Identifying Biomarkers of Response to Immune Checkpoint Inhibitors in Patients with Non-small Cell or Small Cell Lung Cancer

This pilot clinical trial studies how well bronchoscopy with bronchoalveolar lavage works in identifying biomarkers of response to immune checkpoint inhibitors in patients with non-small cell or small cell lung cancer. Bronchoscopy uses a thin, tube-like instrument inserted through the nose or mouth to view the inside of the trachea, air passages, and lungs. Bronchoalveolar lavage washes out the bronchi and alveoli by flushing with a fluid. Bronchoscopy with bronchoalveolar lavage may make it easier to help determine biomarkers that are more present in some cancers than others that will help determine which individuals have a greater or lesser chance of benefiting from immunotherapy.
Not Available
Pilot
Maldonado, Fabien
NCT02937402
VICCTHO16108

Neuropsychological and Behavioral Testing in Younger Patients with Cancer

Multiple Cancer Types

This research trial studies neuropsychological (learning, remembering or thinking) and behavioral testing in younger patients with cancer. Collecting information over time from a series of tests may help doctors develop effective tests to measure neuropsychological and behavioral function of patients with cancer.
Miscellaneous, Neuro-Oncology, Pediatrics
N/A
Friedman, Debra
NCT00772200
COGALTE07C1

Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies

Pediatrics

This clinical trial keeps track of and collects follow-up information from patients who are currently enrolled on or have participated in a Children's Oncology Group study. Developing a way to keep track of patients who have participated in Children's Oncology Group studies may allow doctors learn more about the long-term effects of cancer treatment and help them reduce problems related to treatment and improve patient quality of life.
Pediatrics
N/A
Friedman, Debra
NCT00736749
COGALTE05N1

Late Effects after Treatment in Patients with Previously Diagnosed High-Risk Neuroblastoma

Multiple Cancer Types

This research trial studies late effects after treatment in patients with previously diagnosed high-risk neuroblastoma. Studying late effects after treatment may help to decide which treatments for high-risk neuroblastoma are better tolerated with less side effects over time.
Neuroblastoma (Pediatrics), Pediatrics
N/A
Friedman, Debra
NCT03057626
COGALTE15N2

A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

Hematologic

This study is an access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) in pediatric and adult patients with hematologic malignancies and other indications.
Hematologic
N/A
Kassim, Adetola
NCT01351545
VICCBMT1158

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