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Clinical Trials Search at Vanderbilt-Ingram Cancer Center



A Computerized Program (Neuroplasticity-Based Cognitive Remediation) for the Treatment of Chemotherapy Related Cognitive Impairment in Patients with Breast, Colon, Lymphoma, Endometrial, or Ovarian Cancer

Multiple Cancer Types

This trial studies how well a computerized program called neuroplasticity-based cognitive remediation works for the treatment of chemotherapy related cognitive impairment in patients with breast, colon, lymphoma, endometrial, or ovarian cancer. There are few if any treatments shown to be effective in improving thinking and functioning in patients with attention and memory problems related to cancer treatment. This may leave patients vulnerable to loss of independence and functioning, and to developing depressive symptoms. Neuroplasticity-based cognitive remediation may help to improve thinking, functioning, and depressive symptoms in patients with breast, colon, lymphoma, or ovarian cancer.
Breast, Colon, Lymphoma, Ovarian
N/A
Newhouse, Paul
NCT04230863
VICCSUPP1936

A Medical Food (Enterade) for the Reduction of Bowel Movement Frequency in Patients with Carcinoid Syndrome or Non-Carcinoid Syndrome Neuroendocrine Tumor

Neuroendocrine

This phase II trial studies how well a medical food called enterade works in reducing bowel movement frequency in patients with carcinoid syndrome or non-carcinoid syndrome neuroendocrine tumor. Enterade is a commercially available amino acid-based medical food being developed to manage diarrhea due to carcinoid syndrome or other neuroendocrine tumors. It may also alleviate abdominal pain or discomfort, bloating, cramping and gas secondary to the disease. Enterade may alleviate neuroendocrine tumor associated diarrhea, provide control of bowel-related symptoms, and improve quality of life in neuroendocrine tumor patients with diarrhea.
Neuroendocrine
II
Das, Satya
NCT04073017
VICCGI1943

Ruxolitinib in Preventing Breast Cancer in Patients with High Risk and Precancerous Breast Lesions

Breast

This phase II trial studies how well ruxolitinib before surgery works in preventing breast cancer in patients with high risk and precancerous breast conditions. Ruxolitinib may changes the breast cell when administered to participants with precancerous breast conditions. Ruxolitinib may stop the growth of cells by blocking some of the enzymes needed for cell growth.
Breast
II
Meszoely, Ingrid
NCT02928978
VICCBRE1904

Aspirin in Preventing Colorectal Cancer in Patients with Colorectal Adenoma

Multiple Cancer Types

This phase IIa trial studies how well aspirin works in preventing colorectal cancer in patients with colorectal adenoma. Aspirin may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Colon, Rectal
II
Dai, Qi
NCT02965703
VICCGI17105

Web-Based Physical Activity Intervention in Improving Long Term Health in Children and Adolescents with Cancer

Multiple Cancer Types

This randomized clinical phase III trial studies how well web-based physical activity intervention works in improving long term health in children and adolescents with cancer. Regular physical activity after receiving treatment for cancer may help to maintain a healthy weight and improve energy levels and overall health.
Pediatric Leukemia, Pediatrics
N/A
Esbenshade, Adam
NCT03223753
COGALTE1631

Lactobacillus Plantarum in Preventing Acute Graft Versus Host Disease in Children Undergoing Donor Stem Cell Transplant

Multiple Cancer Types

This randomized phase III trial studies how well Lactobacillus plantarum works in preventing acute graft versus host disease in children undergoing donor stem cell transplant. Lactobacillus plantarum may help prevent the development of gastrointestinal graft versus host disease in children, adolescents, and young adults undergoing donor stem cell transplant.
Gastrointestinal, Pediatrics
III
Kitko, Carrie
NCT03057054
COGACCL1633

A Study of the Safety and Effectiveness of Apixaban in Preventing Blood Clots in Children With Leukemia Who Have a Central Venous Catheter and Are Treated With Asparaginase

Multiple Cancer Types

The purpose of this study is to compare the effect of a blood thinning drug called Apixaban versus no administration of a blood thinning drug, in preventing blood clots in children with leukemia or lymphoma. Patients must be receiving chemotherapy, including asparaginase, and have a central line (a catheter inserted for administration of medications and blood sampling)
Pediatric Leukemia, Pediatric Lymphoma, Pediatric Supportive Care
III
Esbenshade, Adam
NCT02369653
COGACCL1333

Neuroblastoma Maintenance Therapy Trial

Multiple Cancer Types

Difluoromethylornithine (DFMO) will be used in an open label, single agent, multicenter, study for patients with neuroblastoma in remission. In this study subjects will receive 730 Days of oral difluoromethylornithine (DFMO) at a dose of 750 mg / m2 ± 250 mg / m2 BID (strata 1, 2, 3, and 4) OR 2500 mg / m2 BID (stratum 1B) on each day of study. This study will focus on the use of DFMO in high risk neuroblastoma patients that are in remission as a strategy to prevent recurrence.
Endocrine, Neuroblastoma (Pediatrics), Neuroendocrine, Pediatrics
II
Pastakia, Devang
NCT02679144
VICCPED16157

Near Infrared Autofluorescence via PTeye for the Detection of Parathyroid Glands during Total Thyroid Surgery

Thyroid

This trial studies how well infrared autofluorescence via PTeye works in detecting parathyroid glands during total thyroid surgery. Located closely to the thyroid gland are the parathyroid glands, which are important organs that regulate calcium levels in the body. Thus, it is essential for a surgeon to correctly identify this structure when performing a thyroid surgery. PTeye may help surgeon to identify and preserve healthy parathyroid glands during surgery. By assisting the surgeon in correctly identifying parathyroid glands, this device may improve the quality of the operation performed on the patient.
Thyroid
N/A
Solorzano, Carmen
NCT04281875
VICCHN2017

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Efficacy of TAK-169 in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

Multiple Cancer Types

The purpose of this study is to evaluate the safety and tolerability of TAK-169, establish the maximum tolerated dose (MTD) and / or recommended phase 2 dose (RP2D), and to provide a preliminary evaluation of the clinical activity of TAK-169 monotherapy in participants with RRMM.
Multiple Myeloma, Phase I
I
Dholaria, Bhagirathbhai
NCT04017130
VICCHEMP1975

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