Dr. Ho is a pediatric hematologist/oncologist and physician scientist whose research focuses on the molecular mechanisms by which drug transporters contribute to overall chemotherapy disposition and interindividual response to drug therapy in pediatric oncology. Drug transport proteins have important roles in regulating the absorption, distribution, and excretion of many medications as well as endogenous substances. To this extent, a major focus in his lab centers on the contribution of uptake transporters, in particular the organic anion transporting polypeptide (OATP) family and bile acid uptake transporters, to the disposition of pediatric chemotherapeutic agents. In addition, another area of major focus is cancer pharmacogenetics, the study of the role of inheritance in the individual variation in chemotherapy response. Projects are primarily laboratory based with translational promise and rely on background knowledge in the fields of molecular biology and clinical pharmacology. His research has been continuously funded by grants (K08, R01) from the National Institute of General Medical Sciences (NIGMS/NIH) since 2007. Dr. Ho is also a co-investigator on a NIH-funded multicenter clinical trial evaluating the pharmacogenetics of vincristine neuropathy in children with acute lymphoblastic leukemia. Dr. Ho's clinical interests are focused on pediatric stem cell transplantation.