Researchers from Vanderbilt-Ingram Cancer Center will present findings from clinical trials, laboratory discoveries and innovations in caring for patients with hematologic cancers and other blood diseases at ASH 2025 in Orlando, Florida, Dec. 6-9. 

ASH 2025 is the American Society of Hematology Annual Meeting and Exposition. Established in 1958, ASH is the world’s largest professional organization for clinicians and scientists who study blood diseases.  

Three of the presentations from Vanderbilt-Ingram researchers will focus on chimeric antigen receptor T-cell (CAR-T) therapies, a form of immunotherapy that involves treating cancer with white blood cells that have been reengineered to attack cancer cells. Vanderbilt-Ingram is an international leader in advancing the efficacy of and expanding access to CAR-T therapies.

Olalekan Oluwole, MBBS, MPH, associate professor of Medicine, who leads the cellular therapy research program at Vanderbilt-Ingram, will present data on health care resource utilizations of the therapies in U.S. patients treated at newly authorized treatment centers. He will also provide an overview of outcomes for inpatient and outpatient CAR-T treatment. Grace Mercadante, MD, will present data on the impact of clonal hematopoiesis on CAR-T therapy. 

Michael DeBaun, MD, MPH, the J.C. Peterson, MD, Professor of Pediatrics and founder and director of the Vanderbilt-Meharry Sickle Cell Disease Center of Excellence, will speak at a special session focusing on ASH’s sickle cell disease initiative. He will present findings from “Sickle Cell Trait Does Not Cause ‘Sickle Cell Crisis’ Leading to Exertion Related Death: A Systematic Review.” 

Other topics researchers will address include acute myeloid leukemia, myelodysplastic syndrome, drug resistance, potential adverse reactions and risk comparisons of treatments, pediatric blood disorders, multiple myeloma, bispecific antibody treatment, and graft-versus-host disease. 

A complete list of presentations from Vanderbilt researchers follows: 

Sally Momoh, MD – Sex-related differences in silent cerebral infarction burden among adults with sickle cell disease 

Jamila Mammadova, MD – Behind the blood-brain barrier: Contemporary screening practice patterns and trends of central nervous system involvement in acute myeloid leukemia treated with intensive regimens and hypomethylating agent/venetoclax 

Alyssa Jarabek – Impact of innate immune memory on myelodysplastic syndrome progression by TET2-driven inflammation 

Raymond Zhang – VISTA contributes to disease progression in high-risk myelodysplastic syndrome 

Mattew Villaume, MD, PhD – EB2023 primes mitochondria for BCL2 dependence and induces pyroptotic cell death via AMPK signaling and the unfolding protein response 

Grace Mercadante, MD – The impact of clonal hematopoiesis on CAR-T cell therapy outcomes: a single-center analysis 

Ghadeer Dawwas, PhD, MSc, MBA – Risk of serious bleeding with concomitant use of apixaban or rivaroxaban with amiodarone compared to flecainide or sotalol in patients with atrial fibrillation  

Olalekan Oluwole, MBBS, MPH – Real-world health care utilization following CAR-T cell therapy in U.S. patients treated in newly authorized treatment centers 

Erin Christensen, MS, DO – A case series of pediatric patients with congenital thrombotic thrombocytopenia purpura treated with recombinant ADAMTS13 

Andrew Jallouk, MD, PhD – Real-world outcomes of mosunetuzumab use in indolent and aggressive lymphomas  

Bhagirathbhai Dholaria, MBBS – Characterization of a population with newly diagnosed standard risk multiple myeloma by 2025 ims/IMWG definition with exceptional long-term outcomes after fixed duration therapy 

Y. Emily Chu – The acute myeloid leukemia microenvironment is defined by ineffective immune surveillance despite the presence of activated, clonally-expanded CD8 T cells with preserved effector function 

Michael DeBaun, MD, MPH – Findings from “Sickle cell trait does not cause ‘sickle cell crisis’ leading to exertion related death: a systematic review ”

Mattew Villaume, MD, PhD – F1 subunit-specific ATP synthase inhibition disrupts AML mitochondrial metabolism distinctly from other electron transport chain inhibitors 

Lauren Klein, MD, – Early weight gain predicts nutritional recovery in children with sickle cell anemia and severe acute malnutrition in Nigeria 

Olalekan Oluwole, MBBS, MPH – U.S. cost consequence and time toxicity model for advanced therapies in the treatment for relapsed/refractory third-line or later diffuse large B-cell lymphoma: a comparison of axicabtagene ciloleucel with bispecific antibodies 

Olalekan Oluwole, MBBS, MPH – Outcomes of inpatient and outpatient CAR-T in newly authorized treatment centers in the United States 

Elizabeth Pollard, MD – Leukapheresis for acute leukemia with hyperleukocytosis: line complications, resource utilization, and early mortality outcomes 

Carrie Kitko, MD – Long-term treatment duration and safety of axatilimab among patients with chronic graft-versus-host disease in AGAVE-201 

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Kaille Meguiar, DO, MPH, an oncologist in the Division of Pediatric Hematology/Oncology at Monroe Carell Jr. Children’s Hospital at Vanderbilt, has been awarded a $100,000 Hyundai Hope on Wheels Impact Award to research the psychosocial and neurocognitive outcomes of survivors of pediatric, adolescent and young adult cancers.

Hyundai Hope on Wheels, which includes funding from Hyundai Motor America and local dealerships, has awarded more than $2 million in funding to pediatric cancer researchers at Monroe Carell since 2007.

Every year, more than 15,000 children are diagnosed with cancer. Thanks to advancements in treatments, approximately 85% of these children now survive five years or longer. However, there is an increasing need to address the long-term challenges survivors face beyond physical health, including higher rates of anxiety and depression; impaired task efficiency and memory; and long-term problems with attention and executive functions.

With the latest grant award to Monroe Carell, Meguiar’s work will focus on understanding how cancer and its treatment impact survivors’ mental and cognitive well-being, as well as how to better support them and their caregivers.

After completing her DO degree and internal medicine and pediatric residencies at Corewell Health/Helen DeVos Children’s Hospital, Meguiar joined Monroe Carell as a Division of Pediatric Hematology/Oncology fellow. During her fellowship, she developed a research project to identify the risk factors for negative psychosocial outcomes in childhood cancer survivors. Her work earned a National Institutes of Health training grant. With the support of the Hyundai Impact Award, she will expand her research by creating a cohort to study neurocognitive outcomes and develop interventions to improve survivors’ quality of life.

“I am honored to receive this award, which will allow me to continue my work focused on improving the lives of childhood cancer survivors and their families,” said Meguiar, who joined the Vanderbilt faculty in July 2025. “I look forward to advancing our understanding of these challenges and finding ways to make a meaningful difference. Thank you to Hyundai and the local dealerships for supporting this important work to enhance the comprehensive long-term care for childhood cancer survivors.”

Representatives from Hyundai and local dealerships presented a check and an honorary lab coat to Meguiar during a special celebration at Monroe Carell. The event also included patient Greta Ford, 4, and her dad, Adam, and mom, Rachel Modhal, who shared their daughter’s cancer journey with leukemia and described Meguiar as their “rock” through it all.

The event was followed by a “handprint” ceremony where cancer patients dipped their hands in paint and put their handprints on a white Hyundai Palisade, with each handprint representing their personal stories of hope and courage.

“This is about the families who inspire us every day — and the scientific pioneers, like those here today, who are leading innovative and lifesaving research,” said Scott Harrison, senior sales manager for Hyundai Motor America Southern region. “Their breakthroughs are pushing the boundaries of medicine and providing kids with treatments that were unthinkable five or 10 years ago. Because of this, more children are surviving this disease. More kids can play sports, make friends, graduate from high school, build a life for themselves and find their place in the world. More kids have a second chance at life. This is the beating heart of everything we do.”

In celebration of Hope on Wheels’ 27th anniversary, Hyundai will award $27 million in grants to institutions across the country, including Monroe Carell. HHOW has donated more than $277 million in grants since its inception in 1998.

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When 4-year-old Monroe Peterson was diagnosed with cancer, her family was determined to not only rally around her in support but also wanted to make a difference for other patients and families going through a similar experience.

To honor her journey, in November 2024 Monroe’s father, fitness expert and celebrity trainer Gunnar Peterson, started the MVP Challenge on his app, Common Ground, to raise awareness and funds for pediatric cancer efforts at Monroe Carell Jr. Children’s Hospital at Vanderbilt.

The MVP Challenge, named for Monroe Vivian Peterson, included four weeks of guided workouts, question and answer sessions with Gunnar, and an opportunity to win special prizes. The fitness challenge raised funds to support pediatric cancer research, training and care at Monroe Carell.

“For months, Monroe has faced this battle with more grit, determination and positivity than I’ve ever seen,” said Peterson. “She hasn’t backed down; she doesn’t quit; and she moves forward with a smile on her face every day. To honor her strength, we launched the MVP Challenge as a way to come together as a community, push ourselves and raise funds to support children’s cancer treatment and research.”

Monroe was diagnosed with acute myeloid leukemia and completed two rounds of chemotherapy. She received two bone marrow transplants, one from each of her older brothers, and she is now in remission.

During her treatment, Monroe’s family says that she brought positivity, joy and levity to those around her and earned the nickname MVP. Many family members, friends and community members came together in support of the challenge to make it a success.

“We are blown away by the incredible success of the MVP Challenge and know that it would not have been possible without the advocacy, outreach and community engagement work of Gunnar, Jess and the whole Peterson family,” said Debra Friedman, MD, MS, director of the Division of Pediatric Hematology and Oncology at Monroe Carell, deputy director of Vanderbilt-Ingram Cancer Center, and holder of the E. Bronson Ingram Chair in Pediatric Oncology. “This challenge was a wonderful way to honor Monroe’s journey and tenacious spirit.”

Funds raised from the MVP Challenge will support Monroe Carell’s vision to advance personalized pediatric, adolescent and young adult cancer care in the region, specifically leukemia and stem cell research.

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