For the past 20 years, my research has focused on various aspects of RNA processing, from my time as a graduate student, where I studied mechanisms of RNA interference, to my postdoc, where I elucidated connections between pre-mRNA splicing and chromatin remodeling. Over the course of my training, I acquired expertise in molecular mechanisms of RNA metabolism and pre-mRNA splicing, as well as experience generating and analyzing high-throughput genetic interaction map and gene expression datasets. As a natural outgrowth of my postdoctoral work, which revealed an important role for the nucleosome remodeler SWI/SNF in fission yeast splicing, I became increasingly interested in understanding mechanisms through which premRNA splicing is regulated. My independent research program examines regulation of splicing decisions in macrophages upon pathogen sensing and gene expression reprogramming. Specifically, my lab combines transcriptomics with protein biochemistry to understand how splicing factors are functionalized during macrophage activation. To date, my lab has made important contributions to our understanding of how several members of the SR/hnRNP protein families control the innate immune transcriptome and proteome in distinct ways. In addition, my lab has recently embarked on studies of large ribonucleoprotein complexes (e.g., the nuclear RNA exosome), membraneless organelles (e.g., nuclear paraspeckles), and MDS-associated splicing factor mutations in macrophages.