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Lung cancer metastasis-National Cancer Institute \ Winship Cancer Institute of Emory University

Host-Tumor Interactions Research Program

Tumor growth, invasion, and metastasis depend not only on the tumor cell alone, but also on the complex interactions between the tumor cells and their host. The goal of the Host-Tumor Interactions Research Program is to develop a detailed and mechanistic understanding of not just the tumor cell and tumor mutations, but also all the components of the host microenvironment that influence cancer and the response to cancer therapy.

RESEARCH THEMES

With the goal of understanding how complex interactions between tumor cells and their host contribute to cancer, the Host-Tumor Interactions program focuses on four specific research themes:

Understanding how new blood vessels form to feed tumors – and finding ways to block these processes

Identifying molecules involved in communication between tumor cells and their cellular and structural microenvironment

Uncovering how inflammation triggers and promotes cancer

Integrating knowledge about host-tumor interactions to understand how tumors evolve in a changing microenvironment

Meet the Program Members

The Host-Tumor Interactions program is co-led by Mary M. Zutter, M.D., and Jeffrey Rathmell, Ph.D. The basic, translational, and clinical scientists who make up this program are focused on discovering and understanding these interactions, with the ultimate goal of developing strategies to control tumor progression and metastasis by targeting these interactions.


Featured Publications

Program News

December 17, 2020

Study reveals new strategy for reducing tumor growth, metastasis

A team of Vanderbilt investigators has discovered that blocking a certain signaling pathway boosts antitumor immunity and reduces tumor growth and metastasis in models of breast cancer and melanoma.
November 18, 2020

V Scholar Award to support Byndloss’ cancer research

Mariana Byndloss, DVM, PhD, assistant professor of Pathology, Microbiology and Immunology, has received a V Scholar Award from the V Foundation for Cancer Research.
November 12, 2020

New therapeutic target for lung cancer

Continuous activation of cell surface receptors increases signaling that can promote oncogenic transformation. One receptor, EphA2, has been identified as a driver of lung cancer, but its interacting partners are not well characterized.